The Makambako Regional Offices are located in Makambako Town, Njombe Region and is led by the Regional Manager. The zone was established strategically to be able to serve the regions of Njombe, Iringa, Mbeya and Songwe. In order to increase efficiency, this Zone was divided into two zones which are Makambako Zone (Njombe and Iringa) and Songwe (Songwe and Mbeya). Makambako region has warehouses with the capacity to store 22,000 tons of grain.

Currently, the agency is implementing a project to increase grain storage capacity by building modern sheds and warehouses to improve storage structures in the Makambako area. The completion of this project will increase the grain storage capacity from the current 22,000 tons to 62,000 tons.

The grains that are bought, stored and circulated/sold through the Makambako Zone are maize and rice. This region geographically has a good ratio of rice and corn production due to having a large surplus production of grain and has been an attraction point for various buyers of grain due to the abundance and ease of transportation by rail and road.